This is what gives them a potential for abuse and addiction.
The few cases of antihistamine addiction reported in the medical literature are mainly on diphenhydramine (DPH).
A comprehensive review with 185 references for the analysis of commonly prescribed members of an important class of drugs, non-sedating antihistamines (NSAs), is presented.
The review covers most of the methods described for the analysis of cetirizine (CTZ), ebastine (EBS), fexofenadine (FXD), ketotifen (KET) and loratadine (LOR) in pure forms, in different pharmaceutical dosage forms and in biological fluids.
Sleep deprivation played a role in catastrophes such as the Exxon Valdez oil spill off the coast of Alaska, the space shuttle Challenger disaster, and the nuclear accident at the Three Mile Island. National Library of Medicine and National Institutes of Health indicate that there are more than 100 different types of sleep and waking disorders, it is a group of syndromes characterized by disturbance in a person’s hours of sleep, their quality or timing of sleep, or in behaviors or physiological conditions associated with sleep. Marc Halpern defines it as “Sleep disorders are conditions in which a person’s sleep pattern is disturbed, such that a person has a hard time falling asleep, staying asleep, sleeps too much, or sleeps at inappropriate times” . Although it is largely self-regulating, the clock responses to several types of external clues to keep it set twenty-four hours, and scientists call these cues Zeitgebers – a German word meaning “time givers” – it includes, Light, Time Cues, and Melatonin.
Each year, Americans spend an estimated billion on sleep medications and make almost 2 million overnight visits to sleep laboratories, and it cost Americans an estimated 0 billion annually in lost productivity, medical expenses, sick leave, and property and environmental damage. Although sleep is a basic behavior in animals as well as humans, researchers still do not completely understand all of its functions in maintaining health. For light, because of the connections between the eye and light can directly affect the sleep and wake rhythm.
After abusing diphenhydramine or other sedative antihistamines if you suddenly stop taking them, withdrawal symptoms that indicate that you have physical dependence include: Higher doses of DPH and other sedating antihistamines can cause visual and other distortions seen with hallucinogens.
In addition, they can cause an increase in the severity of their other side effects: Sedative effects are increased if these medications are also mixed with other medicines, such as dextromethorphan (DMX) in cough syrups, or are taken with alcohol, opiates such as heroin, sedatives, or tranquilizers, such as Valium.
Perhaps your pet doesn't travel well or gets stressed out by vet exams or professional grooming.According to a report of a patient in the Journal of Child and Adolescent Psychopharmacology in 2010, DPH is abused for its sedative, sleep-inducing, and euphoric effects on the central nervous system.The antihistamines cause addiction by increasing dopamine release in the brain's reward and pleasure centers, typical of addictive substances such as Vicodin and heroin.Most people assume antihistamines are of no concern because of their easy access in over-the-counter allergy, cough, and cold medicines and sleep aids.According to a 2010 review in Allergy, the older, (first generation), sedating antihistamines, developed in the 1940s to 1950s, penetrate the central nervous system (CNS).